APOE aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis
APOE aggregates as seeds for Aβ plaque pathology in Alzheimer’s disease.New research sheds light on the early drivers of Alzheimer’s disease. It reveals how the aggregation
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Magdalena Götz Awarded the Bavarian Order of Merit
TRR 274 Project leader Prof. Magdalena Götz has been awarded the Bavarian Order of Merit by Minister President Dr. Markus Söder.Read the article written by the Helmholtz
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CD8+ T cells drive inflammation in both prodromal and established MS
Exciting new research is shedding light on the role of CD8+ T cells in MS, revealing how they contribute to disease progression.Using single-cell RNA sequencing and
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Oligodendroglial fatty acid metabolism as a central nervous system energy reserve
A recent study by the labs of our members Klaus-Armin Nave and Hannelore Ehrenreich published in Nature Neuroscience uncovers a key role of oligodendroglial cells in
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TFEB governs B-lymphoid fate decisions.
TFEB activation hallmarks antigenic experience of B lymphocytes and directs germinal center fate decisions Antigenic stimulation triggers TFEB to move into the nucleus, where it can
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ERC Starting Grant for Anna-Sophia Wahl
Congratulations to Anna-Sophia Wahl for obtaining a European Research Council (ERC) Starting Grant! From the Ludwig-Maximilians-Universität München Newsroom:”In the ARISE (Activate Repair In StrokE) project, Anna-Sophia Wahl wants
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Key mechanisms identified for improving astrocyte-to-neuron reprogramming
Researchers from the Ludwig Maximilian University of Munich (LMU) made significant progress in unraveling novel mechanisms of glia-to-neuron conversion. By using novel methods in epigenome profiling,
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Amyloidosis triggers age-related oligodendrocyte and myelin damage
Age-related myelin damage leads to white matter inflammation, but its impact on chronic neurodegenerative diseases remains unclear. A recent study reveals that amyloidosis alone can cause
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Possible trigger for autoimmune diseases discovered
Immune system: B cells teach T cells which targets must not be attacked
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The TRR 274 granted for a second funding period
The TRR 274 has received the approval of the DFG, and will continue to receive funding for another 4 years. Spokesperson for the CRC in the
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TRR 274 on the cover of Neuron
Congratulations to the team of scientists around Ozgun Gokce and Mikael Simons! Their work (and cover art) have made it on the cover the current issue
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