Exciting new research is shedding light on the role of CD8+ T cells in MS, revealing how they contribute to disease progression.
Using single-cell RNA sequencing and T cell receptor analysis, scientists compared immune cells from identical twins, where one twin showed no symptoms or only early signs of neuroinflammation.
CD8+ T cells in people with MS show unique changes that make them more migratory, highly activated, and pro-inflammatory. These changes were also seen in twins with subclinical neuroinflammation, indicating that these immune cells may already drive disease in its earliest stages.
Read the full article published in Science Immunology here.
TRR 274 Project leaders contributing to this project: Martin Kerschensteiner (B07, C02) and Thomas Korn (A01).
