TFEB activation hallmarks antigenic experience of B lymphocytes and directs germinal center fate decisions
Antigenic stimulation triggers TFEB to move into the nucleus, where it can either promote B cell survival or lead to apoptosis depending on T cell help. Without T cell support, TFEB increases pro-apoptotic proteins, leading to cell death. But with T cell co-stimulation (via CD40 signaling), B cells are rescued, migrate to lymph follicles, and enhance their antigen presentation, leading to activation and maturation.
Read more on how our scientists from project A08 and A03 came to this proposed mechanism in their open access article in Nature Communications here.
