Oligodendroglial fatty acid metabolism as a central nervous system energy reserve

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Oligodendroglial glucose starvation leads to a gradual myelin loss.

A recent study by the labs of our members Klaus-Armin Nave and Hannelore Ehrenreich published in Nature Neuroscience uncovers a key role of oligodendroglial cells in the brain’s energy metabolism. The research highlights how fatty acid metabolism in oligodendrocytes serves as an energy reserve for neurons during periods of high demand. This discovery offers new insights into how the brain supports its energy needs, especially under stress, and could have implications for understanding neurodegenerative diseases.

You can read more about the findings here.

Klaus-Armin Nave and Hannelore Ehrenreich are project leaders of TRR 274 project C01.