APOE aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis

APOE aggregates as seeds for Aβ plaque pathology in Alzheimer’s disease.

New research sheds light on the early drivers of Alzheimer’s disease. It reveals how the aggregation of apolipoprotein E (APOE) may trigger the formation of amyloid-β plaques.

By studying a transgenic mouse model and human brain autopsies, researchers found that APOE aggregates within microglia activate Aβ amyloidosis through the endo-lysosomal system. This process is influenced by lipid metabolism and the JAK/STAT signaling pathway in microglia.

Read the full article in Immunology here.

TRR 274 Project leaders contributing to this project: Mikael Simons (A06, B01, Z02), Stefan Berghoff (A06), Klaus-Armin Nave (C01), Sarah Jäkel (B07), Martina Schifferer (Z01)